I recently found a need to disable Microsoft Sync Center, so I used the Domain level GPO to do so.  I found one version for Windows 2008 R2 and wrote up what I did for Windows Server 2012 R2.

Windows 2012 R2

Set the following options under Computer Configuration\Policies\Administrative Templates\Network\Offline Files

  • Allow or Disallow use of offline files feature: Disabled
  • Prohibit User Configuration: Enabled
  • Prevent use of Offline Files folder: Enabled
  • Remove ‘Make Available Offline’: Enabled
  • Synchronize all offline files when logging on: Disabled
  • Synchronize all offline files when logging off: Disabled
  • Synchronize offline files before suspend: Disabled

Windows 2008 R2

Set the following options under Computer Configuration\Administrative Templates\Network\Offline Files

  • Allow or Disallow use of offline files feature: Disabled
  • Prohibit User Configuration: Enabled
  • Sync all offline files when logging on: Disabled
  • Sync all offline files when logging off: Disabled
  • Sync offline files before suspend: Disabled
  • Remove ‘Make Offline’: Enabled
  • Prevent use of Offline Files folder: Enabled

Source for Windows 2008 R2 settings http://www.diyitshop.com/2013/02/group-policy-disable-sync-center